Mifepristone Alters Amyloid Precursor Protein Processing to Preclude Amyloid Beta and Also Reduces Tau Pathology
نویسندگان
چکیده
منابع مشابه
Mifepristone alters amyloid precursor protein processing to preclude amyloid beta and also reduces tau pathology.
BACKGROUND Increased circulating glucocorticoids are features of both aging and Alzheimer's disease (AD), and increased glucocorticoids accelerate the accumulation of AD pathologies. Here, we analyzed the effects of the glucocorticoid receptor antagonist mifepristone (RU486) in the 3xTg-AD mouse model at an age where hippocampal damage leads to high circulating corticosterone levels. METHODS ...
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ژورنال
عنوان ژورنال: Biological Psychiatry
سال: 2013
ISSN: 0006-3223
DOI: 10.1016/j.biopsych.2012.12.003